In CALIB_20250421, calibration data prior to April 25 (HST), when an anomaly occurs in CCD 1_34 (DET-ID = 021), are released. For calibration data after April 25, see CALIB_20250425. DARK images are replaced with 202502 run because no dark frame is taken before anomaly occurs. HSC-G SKY images were constructed by combining 200 visit images from this run (202504) and 202502 run. HSC-R2 SKY images were constructed by combining 200 visit images from this run (202504), 202502 run, and 202412 run. HSC-Z SKY images were constructed by combining 200 visit images from this run (202504) and 202502 run. NB0656 SKY images were constructed by combining 73 visit images from this run (202504), 202206 run, and 201406 run. NB0872 SKY images were constructed by combining 129 visit images from this run (202504), 202502 run, 202412 run, 202406 run, 202404 run, 202308 run, and 202305 run.